Guillain-Barré syndrome and its variants: a case of acute motor-sensory axonal neuropathy in Jamaica / Síndrome de Guillain-Barré y sus variantes: un caso de la neuropatía axonal sensorial motor aguda en Jamaica

This paper reports a case of a Jamaican young woman who experienced flaccid quadriparesis and bulbar weakness over a three-week period after a gastrointestinal illness. Nerve conduction studies confirmed an axonal type neuropathy consistent with the acute motor-sensory axonal neuropathy variant of the Guillain-Barré syndrome. Recovery, although evident, was slow and was augmented after a course of intravenous immunoglobulin. The patient was discharged from hospital after three months but was re-admitted one week later and eventually succumbed to complications of the illness. This case serves as a reminder that Guillain-Barré syndrome is now the most common cause of acute flaccid paralysis and should be considered early in all patients presenting with flaccid quadriparesis.

El presenta trabajo reporta el caso de una joven jamaicana que experimentó debilidad bulbar y cuadriparesiaflácida por un período de tres semanas después de una enfermedad gastrointestinal. Los estudios de conducción nerviosa confirmaron una neuropatía de tipo axonal en correspondencia con la variante de la neuropatía axonal sensorial motora aguda del síndrome de Guillain-Barré. La recuperación, aunque evidente, fue lenta, y aumentó después de que se le aplicara inmunoglobulina intravenosa. La paciente fue dada de alta del hospital después de tres meses, pero fue ingresada de nuevo una semana más tarde, falleciendo finalmente a causa de las complicaciones de la enfermedad. Este caso sirve como recordatorio de que el síndrome de Guillain-Barré es ahora la causa más común de parálisis flácida aguda, y debe tenerse en cuenta temprano en todos los pacientes que acuden con cuadriparesia flácida.

The prevalence and significance of oestrogen receptor (ER) positivity in breast cancer at the University Hospital of the West Indies, Jamaica / Prevalencia y significación de la positividad del receptor de estrógeno (RE) en el cáncer de mama en el Hospital Universitario de West Indies, Jamaica

OBJECTIVE: To identify the prevalence of oestrogen receptor (ER) positivity, and determine the relationship of ER status with patient and tumour characteristics, in patients with breast cancer. SUBJECTS AND METHODS: A retrospective review was conducted regarding the prevalence and clinical significance of ER in patients with breast cancer at the University Hospital of the West Indies (UHWI). Oestrogen receptor status results of 243 patients treated at UHWI were collected for the period January 1, 2002 to December 31, 2009. One hundred and ninety-nine were available for review. RESULTS: Oestrogen receptor status was positive in 125 (63%) and negative in 74 (37%) patients. Mean age at diagnosis was 52.6 ± 13.0 years for the ER positive group and 58.5 ± 14.23 years for the ER negative group. Postmenopausal women accounted for 55.2% and 64.9% of the ER positive and negative groups, respectively. Mean BMI was 28.0 kg/m² and 29.6 kg/m² for the ER positive and negative groups, respectively. Menarche occurred mainly between ages 12 and 13 years for both groups. Mean age at 1st parity was 23.4 years for the ER positive and 21.4 years for the ER negative group with median parity of two for both groups. The most prevalent risk factors were oral contraceptive pill (OCP) use (24.3% for the ER positive group, 17.1% for the ER negative group), family history of breast cancer (12.0%; 13.4%) and previous smoking (8.4%; 6.9%). Tumour node metastasis (TNM) stage was Stage II in most cases (46%; 49%). Infiltrating ductal histology was most common (81.5%; 87.7%). Her 2/ neu status was negative for most patients (91.3%; 91.5%). Most patients were disease free (77.6%; 70.0%) after an average follow-up period of 3.5 years. More persons in the ER negative group had locoregional recurrence (8%) and metastases (22%). CONCLUSIONS: Oestrogen receptor positive cohort was more prevalent. The ER negative group was older (p = 0.003).

OBJETIVO: Identificar la prevalencia del receptor de la positividad de receptor de estrógeno (RE), y determinar la relación del estatus de RE con el paciente y las características del tumor, en las pacientes con cáncer de mama. SUJETOS Y MÉTODOS: Se realizó un estudio retrospectivo con respecto a la prevalencia e importancia clínica del RE en los pacientes con cáncer de mama en el Hospital Universitario de West Indies (UHWI). Se recogieron los resultados del estatus del receptor de estrógeno de 243 pacientes tratados en UHWI en el periodo del 1 de enero de 2002 al 31 de diciembre de 2009. Ciento noventa y nueve estuvieron disponibles para examen. RESULTADOS: El estatus del receptor de estrógeno fue positivo en 125 (63%) y negativo en 74 (37%) pacientes. La edad promedio al momento del diagnóstico fue 52.6 ± 13.0 años para el grupo de RE positivo y 58.5 ± 14.23 años para el RE grupo negativo. Las mujeres menopáusicas representaron el 55.2% y el 64.9% del RE de los grupos positivos y negativos respectivamente. El índice de masa corporal (IMC) promedio fue 28.0 kg/m2 y 29.6 kg/m2 para el RE de los grupos positivos y negativos respectivamente. La menarquia ocurrió principalmente entre las edades de 12 y 13 años para ambos grupos. La edad promedio en la primera paridad fue 23.4 años para el grupo de RE positivo y 21.4 años para el de RE negativo, siendo la paridad mediana igual a dos para ambos grupos. Los factores de riesgo de mayor preponderancia fueron el uso de anticonceptivos orales (ACO) (24. 3% para el grupo de RE positivo, 17.1% para el grupo RE negativo); historia familiar de cáncer de mama (12.0%; 13.4%); y hábito de fumar con anterioridad (8.4%; 6.9%). De acuerdo con la estadificación tumor-nódulo-metástasis (TNM), se trataba de la Etapa II en la mayor parte de los casos (46%; 49%). La histología ductal infiltrante fue la más común (81.5%; 87.7%). El estatus Her2/neu fue negativo para la mayoría de las pacientes (91.3%; 91.5%). La mayoría de las pacientes se hallaban libres de enfermedad (77.6%; 70.0%) después de un periodo promedio de seguimiento de 3.5 años. En el grupo de RE negativo había más personas con recurrencia locoregional (8%) y metástasis (22%). CONCLUSIONES: La cohorte positiva del receptor de estrógeno positiva fue más prevaleciente. El grupo negativo de RE fue de mayor edad (p = 0.003).

Lateral medullary infarct/Wallenberg Syndrome: Jamaica / Síndrome de Wallenberg/Infarto medular lateral: Jamaica

We describe two cases of lateral medullary syndrome at the University Hospital of the West Indies, Mona, Jamaica. This diagnosis is often missed and not well understood, so we will discuss the underlying pathophysiology.

Se describen dos casos de síndrome medular lateral en el Hospital Universitario de West Indies, Mona, Jamaica. Este diagnóstico pasa a menudo inadvertido y no es bien entendido. Por esa razón se discute aquí la patofisiología subyacente.

Acute limb ischaemia in a septic patient with diabetic ketoacidosis / Isquemia aguda de miembros en un paciente septico con cetoacidosis diabetica

This is a patient with septicaemia and diabetic ketoacidosis who developed an acute ischaemic lower limb from an arterial thrombus. The patient had decreased protein S function.

Se trata de un paciente con septicemia y cetoacidosis diabética que desarrolló una isquemia aguda en un miembro inferior a partir de un trombo arterial. El paciente presentaba función disminuida de la proteína S.

A case of lupus-associated pancreatitis in Jamaica / Un caso de pancreatitis asociada con lupus en Jamaica

Pancreatitis complicating a diagnosis of systemic lupus erythematosus (SLE) is rarely reported in the literature and there are no known published cases thus far in the Caribbean. A 50-year old female diagnosed with SLE and discoid lupus erythematosus (DLE) since 1990, presented in February, 2009, to the University Hospital of the West Indies (UHWI), Kingston, Jamaica, with symptoms suggestive of lupus pancreatitis. Serum amylase level was 2341 IU/L and serum lipase was 203 IU/L. Pancreatitis has a 3-8% rate of occurrence in adult patients with SLE. Aetiology and management of this entity remains controversial in these cases, but one must bear the diagnosis in mind, when faced with a SLE patient presenting with abdominal pain, vomiting and diarrhoea.

La pancreatitis que complica el diagnóstico del lupus eritematoso sistémico (LES), raramente se reporta en la literatura, y hasta hoy no se conoce de caso alguno publicado en el Caribe. Una mujer de 50 años de edad, a quien se le diagnosticara lupus eritematoso sistémico (LES), y lupus eritematoso discoide (LED) desde 1990, acudió en febrero de 2009 al Hospital Universitario de West Indies, Kingston, Jamaica, con síntomas que sugerían una pancreatitis por lupus. El nivel de amilasa sérica fue 2341 IU/L y el de lipasa sérica fue 203 IU/L. La pancreatitis tiene una tasa de ocurrencia de 3-8% en pacientes adultos con LES. La etiología y el tratamiento de esta entidad siguen siendo controversiales en estos casos, pero se debe tener presente el diagnóstico frente a pacientes de SLE que presenten dolor abdominal, vómito y diarrea.

Potentials and Limits of Modern Optical Instruments for the Non-Invasive Investigation of The Anterior Eye Segment

 Considerabel progress has been made in the development and design of optical instruments that allow precise measurements of the morphological and also physiological properties of the transparent media of the eye namely the cornea and the lens.  Cameras that are built according to the Schemipflug principle (Topcon SL-45, Zeiss SLC, Oxford Case 2000, Nidex EAS 1000) allow precise measurements of light scattering and biometrical parameters of the cornea and the lens.  Cataracts can be monitored with respect to their location, development and progress, so that also prospective experimental and epidemiological data are obtained.  The technique of retroilumination, which is already implemented in the Case 2000 and the EAS 1000, can provide additional information but on its own did not prove to be reliable for clinical studies.  At the moment, new diagnostic fields are opened with the application of laser light scattering combined with the confocal principle to the measurement of scattering, fluorescence and absorption in the eye.  These techniques carry the potential to measure the dynamics of physiological processes in the tissue as well as the distribution of drugs.

Descriptive epidemiology of cases of acute myocardial infarction in Tobago / Epidemiología descriptiva de casos de infarto agudo del miocardio en Tobago

OBJECTIVES: The goal of this study is to identify co-morbidities associated with acute myocardial infarction in Tobago. METHODS: This was a longitudinal retrospective study of myocardial infarction at the Tobago Regional Hospital in two selected periods: January 2007 to April 2007 and January 2008 to April 2008. Data were retrieved from the patients' medical records. These included co-morbid conditions eg hypertension, diabetes mellitus, dyslipidaemia, ESRD, whether history of smoking or cocaine use and if any prior care. In the former period, 11 cases were confirmed as having myocardial infarction and 27 cases in the latter period. RESULTS: In 2007 and 2008, all cases had dyslipidaemia (LDL > 100 mg/dL) and were hypertensive. There were 36.4% of cases in 2007 that had diabetes mellitus, compared to 33.3% cases in 2008 and 9.1% had chronic kidney disease in 2007, compared to 25.9% in 2008. CONCLUSION: The most common co-morbidities associated with acute myocardial infarction in Tobago are dyslipidaemia, hypertension and diabetes mellitus, with ESRD, smoking and cocaine use less so. Many of these patients had never received prior care.

OBJETIVOS: El objeto de este estudio fue identificar las comorbilidades asociadas con el infarto agudo del miocardio en Tobago. METÓDOS: Se realizó un estudio retrospectivo longitudinal del infarto del miocardio en el Hospital Regional de Tobago, en dos períodos: enero de 2007 a abril de 2007, y enero de 2008 a abril de 2008. Los datos fueron obtenidos a partir de las historias clínicas de los pacientes. Estos datos incluyeron condiciones co-mórbidas, por ejemplo, hipertensión, diabetes mellitus, dislipidemia, ERFT, historia de hábito de fumar o uso de cocaína, y cualquier atención previa del caso, si la hubiese. En el primero de estos períodos, se confirmó que 11 casos tenían infarto del miocardio, en tanto en el último caso se confirmaron 27 casos. RESULTADOS: En 2007 y 2008, todos los casos padecían de dislipidemia (LDL > 100 mg/dL) y eran hipertensos. El 36.4% de los casos en 2007 sufría de diabetes mellitus, en comparación con el 33.3% de los casos en 2008. El 9.1% tenía la enfermedad renal crónica en 2007, en comparación con el 25.9% en 2008. CONCLUSIÓN: Las comorbilidades más comunes asociadas con el infarto agudo del miocardio en Tobago son la dislipidemia, la hipertensión y la diabetes mellitus, y en menor grado la ERET, el hábito de fumar, y el consumo de cocaína. Muchos de estos pacientes no habían recibido nunca atención con anterioridad.

A comparison of prevalence rates of genital ulcers among persons attending a sexually transmitted disease clinic in Jamaica

Two cross-sectional surveys were undertaken, from December 1982 to August 1983 and from November 1990 to January 1991, to estimate the prevalence rates of genital ulcer disease (GUD) in all patients presenting with a new sexually transmitted disease (STD) complaint to the STD clinic at the Comprehensive Health Centre in Kingston, Jamaica. Diagnosis of syphilis and human immunodeficiency virus (HIV) infection was based on results of laboratory tests, but diagnosis of other STDs was based on clinical features. Data from these two surveys were compared, and reported national annual incidence data for GUD reviewed. In 1982/83 6.8 percent of 23,050 patients had GUD, men (9.3 percent) more often than women (4.2 percent; p < 0.001). In 1990/91 the prevalence rate was 12.8 percent with increased rates for both men (18.2 percent) and women (6.8 percent; p < 0.001). In patients with GUD, a clinical diagnosis of genital herpes was made, in 1982/83 and 1990/91, respectively, in 16.8 percent and 7.8 percent of the patients; syphilis, in 12.9 percent and 18.8 percent; chancroid, in 12.4 percent and 13.3 percent; viral warts, in 5.7 percent and 6.3 percent; lymphogranuloma venereum, in 4.1 percent and 3.9 percent; and granuloma inguinale, in 3.6 percent and 2.3 percent. In men the rate for syphilis was 19 percent in 1990/91 and 8 percent in 1982/83 (p=0.001); and for genital herpes it was 7 percent in 1990/91 and 17 percent in 1982/83 (p=0.025). These reversals were attributed to intense media coverage of herpes in 1982/83. There was no difference in prevalence rates between the two surveys for these diseases in women, or for lymphogranuloma venereum, granuloma inguinale and genital warts in men and women. A clinical diagnosis could not be made in 44.4 percent of cases in 1982/83 (particularly in men), and in 47.6 percent of cases in 1990/91. GUDs faciltate transmission and adversely affect the prognosis of HIV. The increase in their prevalence has implications for the evolution of the local HIV epidemic, and hould be addressed effectively by stregthening the STD/HIV control programme.

Survey of patients with sexually transmitted diseases seen by private physicans in Jamaica

A survey of physicians in private practice in Jamaica was conducted between March and September 1993 to provide a descriptive analysis of the occurrence of patients with sexually transmitted diseases (STDs) seen in their practices. Questionnaires were delivered to 371 physicians of whom 127 (34 percent) responded, completing 683 (men 353, women 330) individual patient questionnaires. Each physician collected data over a period of one week. The median ages of the men and women were 27 years and 26 years, respectively. 464 (68 percent) patients were being seen for the first time for symptomatic STDs, and the visit was a follow-up for 132 (19 percent) who had been previously diagnosed; 40 (6 percent) patients were asymptomatic contacts referred by a sex partner, and 12 (2 percent), who were asymptomatic, asked for a "check up". A history of previous STD was given by 358 (52 percent) patients. 470 (69 percent) patients had a genital discharge (M, 65 percent; F, 73 percent; p = 0.017), 52 (8 percent) had anogenital lesions (M, 10 percent; F, 5 percent; p = 0.013) and 45 (7 percent), inguinal lymphadenopathy (M, 10 percent; F, 3 percent; p = 0.002). Among women, 131 (40 percent) had lower abdominal pain on examination and 105 (32 percent) had cervical excitation tenderness or pain suggesting pelvic inflammatory disease (PID). A working diagnosis of gonorrhoea was made in 273 (40 percent) patients, trichomoniasis in 121 (18 percent), nongonococcal infection in 114 (17 percent), syphilis in 60 (9 percent), herpes genitalis in 20 (3 percent) and chancroid in 11 (2 percent). PID was diagnosed in 121 (37 percent) women and nongonococcal urethritis in 98 (28 percent) men. The most frequently prescribed treatments were for chlamydia, gonorrhoea and trichomoniasis. In general, working diagnoses correlated well with clinical observations and treatment given, matched with diagnosis according to national guidelines. A comparison of the STD burden between the public and private sectors was not possible because of sample bias.

Studies on prevalence of strongyloides infection in Holambra and Maceio, Brazil, by the agar plate faecal culture method

Foi feito levantamento sobre a prevalencia da infeccao por Strongyloides stercoralis em tres areas do Brasil, atraves do desenvolvimento de metodo de cultura de fezes (cultura em placa de agar). A infeccao por Strongyloides foi confirmada em 11,3 por cento de 432 pacientes examinados. A eficacia do diagnostico pela cultura em placa de agar foi de 93,9 por cento comparado com apenas 28,5 por cento e 26,5 por cento pelo metodo de Harada-Mori de cultura em papel de filtro e metodo de concentracao de fezes, quando amostras de fezes foram examinadas simultaneamente por estes tres metodos. Entre as 49 amostras positivas, aproximadamente 60 por cento foram confirmadas como positivas somente pela cultura em placa de agar. Estes resultados indicam que a cultura em placa de agar e um novo metodo sensivel para o diagnostico correto da infeccao cronica pelo Strongyloides

Is under-reporting of AIDS a problem in Jamaica?

A survey of physicians in Jamaica was conducted between March and September, 1993 in order to estimate the level of reporting of HIV and AIDS. A questionnaire was delivered to nearly all of approximately 1,200 physicians practising in Jamaica. Completed questionnaires were received from 518, a response rate of 35 per cent. Of the physicians responding, 46 per cent were in private practice only, 22 per cent in the public sector only and 32 per cent in both. Two-thirds (66 per cent) of the physicians in private practice had not diagnosed a case of AIDS and 65 had not had a patient with a positive HIV test result. Half (54 per cent) of the private physicians had reported all their AIDS cases, 8 per cent had reported some and 38 per cent (45 doctors) had reported none. The main reasons for not reporting were: "thought someone else had reported" (15 doctors), concern for confidentiality (11) and not knowing where to report (8). Only 9 per cent of private practitioners were currently seeing an AIDS patient and 12 per cent were seeing an HIV-infected person. Of physicians with current AIDS patients 16 per cent preferred not to report, 21 per cent intended to report and 63 per cent had reported. Nearly one-third (29 per cent) of private practitioners expressed reservations about treating persons with HIV/AIDS. Most (75 per cent) public sector physicians had seen one or more AIDS patients. Sixty-four per cent of these physicians said that all of their AIDS cases were reported, 4 per cent said some, 4 per cent said none and 28 per cent didn't know. Reporting of AIDS cases is better in the public sector than among private physicians. It is likely that some, if not many, of the AIDS cases not reported by private physicians are reported when admitted to hospital. It is not possible to estimate the precise level of under reporting of AIDS in Jamaica from this survey. However, more needs to be done to address the reservations of some private physicians and convince them of the need for timely reporting of HIV/AIDS cases

Efeito do captopril na dilataçäo ventricular progressiva após infarto do miocárdio anterior / Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction

Realizamos estudo duplo-cego, comparativo com placebo para determinar se a dilataçäo ventricular continua durante a fase de convalescença após infarto do miocárdio e se a terapêutica com captopril altera esse processo. Cinqüenta e nove pacientes com primeiro infarto do miocárdio anterior e fraçäo de ejeçäo de 45 por cento ou menos se submeteram a cateterismo 11 e 31 dias depois do infarto, se näo estivessem em insuficiência cardiáca congestiva evidente. Foram entäo randomicamente alocados para placebo ou captopril e acompanhados por um ano. Repetiu-se a cateterizaçäo para avaliar as mudanças intervalares na funçäo hemodinâmica e volume ventricular esquerdo. Trinta e oito pacientes masculinos foram avaliados, a cada três meses, para prova de exercício máximo em esteira. Näo foram detectadas diferenças na situaçäo basal em relaçäo às variáveis clínicas, hemodinâmicas ou de ventriculografia quantitativa. Durante um ano de acompanhamento o volume distólico final do ventrículo esquerdo aumentou em média (ñ DP) de 21 ñ 8ml (P < 0,02) no grupo placebo, mas somente 10 ñ 6ml (P näo significante) no grupo captopril. A pressäo de enchimento ventricular esquerda permaneceu elevada com placebo mas diminuiu (P < 0,01) de 36 pacientes que era de alto risco para dilataçäo ventricular, por terem uma oclusäo persistente da artéria coronária anterior esquerda, captopril preveniu dilataçöes ventriculares futuras (P < 0,05). Pacientes que receberam captopril tambem tiveram aumento na capacidade de exercício (P < 0,05). Este estudo preliminar indica que após infarto anterior do miocárdio, a dilataçäo ventricular é progressiva e captopril pode atenuar esse processo, reduzir as pressöes de enchimento, e melhorar a tolerância ao exercício

A practical manual on sexually transmitted diseases for the Caribbean

This manual is intended as a guide for a systematic approach to STD management, and as an easy reference for the busy clinician.

A practical manual on sexually transmitted diseases for the Caribbean

The manual is intended for use as a reference tool by physicians engaged in STD control programmes in the Caribbean. All presumptive diagnosis warrant full treatment and follow-up